Kratom And Fentanyl Bluelight
Common or Street Names: Thang, Krypton, Kakuam, Thom, Ketum, Biak-Biak (common name in Thailand) What is Kratom?Kratom (Mitragyna speciosa) is a tropical evergreen tree from Southeast Asia and is native to Thailand, Malaysia, Indonesia and Papua New Guinea. Kratom, the original name used in Thailand, is a member of the Rubiaceae family.
How does Kratom Work? As researched in mice, kratom targets a part of the brain that responds to drugs like morphine, codeine, and fentanyl. These types of drugs are called opioids. Kratom, simply put, is an opioid agonist. This means that it mimics the effects of opioid drugs such as morphine, oxycodone, hydrocodone and heroin.
Other members of the Rubiaceae family include coffee and gardenia. The leaves of kratom are consumed either by chewing, or by drying and smoking, putting into capsules, tablets or extract, or by boiling into a tea. The effects are unique in that stimulation occurs at low doses and opioid-like depressant and euphoric effects occur at higher doses. Common uses include treatment of pain, to help prevent withdrawal from opiates (such as prescription or ), and for mild stimulation. Traditionally, kratom leaves have been used by Thai and Malaysian natives and workers for centuries.
The stimulant effect was used by workers in Southeast Asia to increase energy, stamina, and limit fatigue. However, some Southeast Asian countries now outlaw its use.In the US, this herbal product has been used as an alternative agent for muscle pain relief, diarrhea, and as a treatment for opiate addiction and withdrawal. However, its safety and effectiveness for these conditions has not been clinically determined, and the FDA has raised serious concerns about toxicity and possible death with use of kratom.As published on February 6, 2018, the FDA notes it has no scientific data that would support the use of kratom for medical purposes. In addition, the FDA states that kratom should not be used as an alternative to prescription opioids, even if using it for opioid withdrawal symptoms.
As noted by the FDA, effective, FDA-approved prescription medications, including buprenorphine, methadone, and naltrexone, are available from a health care provider, to be used in conjunction with counseling, for opioid withdrawal. Also, they state there are also safer, non-opioid options for the treatment of pain.On February 20, 2018 the US Centers for Disease Control and Prevention (CDC) it was investigating a multistate outbreak of 28 salmonella infections in 20 states linked to kratom use. They noted that 11 people had been hospitalized with salmonella illness linked to kratom, but no deaths were reported. Those who fell ill consumed kratom in pills, powder or tea, but no common distributors has been identified.Learn More: DEA Scheduling of KratomKratom was on the DEA’s list of drugs and chemicals of concern for several years. On August 31, 2016, the DEA published a notice that it was planning to place kratom in, the most restrictive classification of the Controlled Substances Act.
Its two primary active ingredients, mitragynine and 7-hydroxymitragynine (7-HMG), would be temporarily placed onto Schedule I on September 30, according to a filing by the DEA. The DEA reasoning was 'to avoid an imminent hazard to public safety. The DEA did not solicit public comments on this federal rule, as is normally done.However, the scheduling of kratom did not occur on September 30th, 2016. Dozens of members of Congress, as well as researchers and kratom advocates have expressed an outcry over the scheduling of kratom and the lack of public commenting. The DEA withheld scheduling at that time and opened the docket for public comments.Over 23,000 public comments were collected before the closing date of December 1, 2016, according to the American Kratom Association. The is a lobbying and advocacy group in support of kratom use. The American Kratom Association reports that there are a 'number of misconceptions, misunderstandings and lies floating around about Kratom.'
As reported by the Washington Post in December 2016, Jack Henningfield, an addiction specialist from Johns Hopkins University and Vice President, Research, Health Policy, and Abuse Liability at Pinney Associates, was contracted by the American Kratom Association to research the kratom's effects. In Henningfield's 127 page report he suggested that kratom should be regulated as a natural supplement, such as St. Johns Wort or Valerian, under the FDA's Food, Drug and Cosmetic Act. The American Kratom Association then submitted this report to the DEA during the public comment period.review by the DEA of the public comments in the kratom docket, review of recommendations from the FDA on scheduling, and determination of additional analysis. Possible outcomes could include emergency scheduling and immediate placement of kratom into the most restrictive Schedule I; routine DEA scheduling in schedule 2 through 5 with more public commenting; or no scheduling at all. The timing for the determination of any of these events is unknown.State laws have banned kratom use in several states including, Indiana, Tennessee, Wisconsin, Vermont, Arkansas, Alabama and the District of Columbia. These states classify kratom as a. Kratom is also noted as being banned in Sarasota County, Florida, San Diego County, California, and Denver, Colorado. The FDA's analysis from February 2018 included 44 reported deaths associated with the use of kratom.
According to Governing.com, legislation was considered last year in at least six other states — Florida, Kentucky, New Hampshire, New Jersey, New York and North Carolina. What is the Pharmacology of Kratom?As reported in February 2018, from analysis that kratom has opioid properties. More than 20 alkaloids in kratom have been identified in the laboratory, including those responsible for the majority of the pain-relieving action, the indole alkaloid mitragynine, structurally related to yohimbine. Mitragynine is classified as a kappa-opioid receptor agonist and is roughly 13 times more potent than morphine. Mitragynine is thought to be responsible for the opioid-like effects.Kratom, due to its opioid-like action, has been used for treatment of pain and opioid withdrawal. Animal studies suggest that the primary mitragynine pharmacologic action occurs at the mu and delta-opioid receptors, as well as serotonergic and noradrenergic pathways in the spinal cord.
Stimulation at post-synaptic alpha-2 adrenergic receptors, and receptor blocking at 5-hydroxytryptamine 2A may also occur. The 7-hydroxymitragynine may have a higher affinity for the opioid receptors. Partial agonist activity may be involved.Additional animals studies show that these opioid-receptor effects are reversible with the opioid antagonist.Time to peak concentration in animal studies is reported to be 1.26 hours, and elimination half-life is 3.85 hours. Effects are dose-dependent and occur rapidly, reportedly beginning within 10 minutes after consumption and lasting from one to five hours. Kratom Effects and ActionsMost of the psychoactive effects of kratom have evolved from anecdotal and case reports. Kratom has an unusual action of producing both stimulant effects at lower doses and more CNS depressant side effects at higher doses. Stimulant effects manifest as increased alertness, boosted physical energy, talkativeness, and a more social behavior.
At higher doses, the opioid and CNS depressant effects predominate, but effects can be variable and unpredictable.Consumers who use kratom anecdotally report lessened anxiety and stress, lessened fatigue, pain relief, sharpened focus, relief of withdrawal symptoms,Beside pain, other anecdotal uses include as an anti-inflammatory, antipyretic (to lower fever), antitussive (cough suppressant), antihypertensive (to lower blood pressure), as a local anesthetic, to lower blood sugar, and as an antidiarrheal. It has also been promoted to enhance sexual function. None of the uses have been studied clinically or are proven to be safe or effective.In addition, it has been reported that opioid-addicted individuals use kratom to help avoid side effects when other opioids are not available. Kratom withdrawal side effects may include irritability, anxiety, craving, yawning, runny nose, stomach cramps, sweating and diarrhea; all similar to opioid withdrawal.Deaths reported by the FDA have involved one person who had no historical or toxicologic evidence of opioid use, except for kratom. In addition, reports suggest kratom may be used in combination with other drugs that have action in the brain, including illicit drugs, prescription opioids, benzodiazepines and over-the-counter medications, like the anti-diarrheal medicine, loperamide (Imodium AD). Mixing kratom, other opioids, and other types of medication can be dangerous. Kratom has been shown to have opioid receptor activity, and mixing prescription opioids, or even over-the-counter medications such as loperamide, with kratom may lead to serious side effects.
Extent of Kratom UseOn the Internet, kratom is marketed in a variety of forms: raw leaf, powder, gum, dried in capsules, pressed into tablets, and as a concentrated extract. In the US and Europe, it appears its use is expanding, and recent reports note increasing use by the college-aged population.The DEA states that drug abuse surveys have not monitored kratom use or abuse in the US, so its true demographic extent of use, abuse, addiction, or toxicity is not known. However, as reported by the DEA in 2016, there were 660 calls to U.S. Poison centers related to kratom exposure from 2010 to 2015. Kratom Side Effects and Health HazardsExpected opioid-like side effects that may occur with kratom include:.
Sedation. Nausea. Sweating. Dry mouth.
Increased urination. Loss of appetite.
Itching. Constipation. Dizziness. ConfusionCase reports describe the following adverse effects from kratom: addiction, withdrawal, hypothyroidism, and liver injury, aching of muscles and bones and jerky limb movements.Kratom addiction and chronic use has led to cases of psychosis with hallucinations, delusion, and confusion. High-dose use may lead to fast heart rate (tachycardia) and low blood pressure (hypotension). Tremor, anorexia and weight loss are other possible side effects with long-term use.Seizures have been reported when kratom was combined with modafinil in at least one case report.
The DEA has also reported seizure adverse events with recreations kratom use.A case series from Kronstad, et al. Described a fatal drug interaction with kratom. A substance, dubbed “Krypton” - a mixture of mitragynine and a metabolite of tramadol - was found post-mortem in nine people in Sweden over a one year period., an opioid-like prescription pain drug, was most likely added to kratom to boost its narcotic-like effect.In and, the FDA a public health advisory about deadly risks associated with kratom. There have been 44 reports of Kratom-related deaths, sometimes used in combination with other illicit drugs, prescription drugs, or over-the-counter agents such as loperamide (Imodium).As with many herbal alternatives, designer drugs, or sold on the Internet, the possibility exists that kratom may also be contaminated with illegal drugs, black market prescription medications, or even poisonous products. Consumers should avoid buying unknown drug products from the Internet.
When combined with other drugs - recreational, prescription, or alcohol - the effects of kratom are unknown and may be dangerous. Is Kratom Addictive?Kratom is well-known to be addictive, as found with traditional use by natives over many years in Southeast Asian countries. Withdrawal effects similar to narcotic withdrawal and drug-seeking behaviors have been described in users in Southeast Asia.
Many Southeast Asian countries have restricted the use of kratom due to the potential for abuse.The fact that kratom is derived from a plant should not lead consumers to be believe it 100% safe and 'all-natural'. While certainly not all botanicals have dangerous properties, drugs with dangerous effects can come from botanicals, for example, heroin (opium poppy), cocaine (coca leaves), and nicotine (tobacco). Will a Drug Test Identify Kratom Use?Currently, kratom is not included in standard drug screens in the US. Kratom tests are available for screening but are not widely available. ConclusionKratom, an herbal product that originated in Southeast Asia, is being used in the US to ease anxiety, treat chronic pain and to reverse opioid withdrawal symptoms; often purchased over the Internet. Recreational use may be on the rise, too.
Use in coffee shops has been reported.The primary psychoactive component, mitragynine, is many times more potent than morphine., and is in the process of evaluating kratom for placement into controlled substances scheduling.Placing kratom into schedule I would place it in the same category as heroin, LSD or marijuana, and prevent access for medical research, a concern for many experts, consumers, and advocacy groups. Lack of quality scientific evidence confounds the evaluation of the safety of kratom. Concerns also exist that the general public would not be able to identify or confirm the quality or purity of kratom from any Internet source.The FDA has warned consumers not to use any products labeled as containing kratom. As of February 2018, the FDA has reported on 44 related deaths linked with kratom use, often in use with other substances.Health care professionals and consumers related to products containing kratom to the FDA’s MedWatch program. See Also.
So I know this sounds a little bit ridiculous but is there any chance that if I wear a 75mcg fentanyl patch for 3 days, that the kratom withdrawals will be more drawn out but less intense? The reason why I say fentanyl is because I tried this approach before for a day and it didn't fully get rid of the withdrawals, maybe only like 30% of the withdrawals, but made it more manageable. So I'm thinking if I wear the patch for 3 days, most of the major withdrawals will be gone, and after I take the patch off I'll just deal with the rest of the two days.What do you guys think? I'm just having one hell of a time trying to get off of it. Why would you expect withdrawal to lessen while on the fentanyl patch?
I'm sure your aware that not only are they completely cross tolerant, but fentanyl is way stronger right? If anything you'll be in a slightly worse position after the patch wears off, you certainly won't be making any progress. If detoxing from opiates was as easy as switching opioids for the duration of withdrawal there would be no addicts on maintenance therapy.Get ahold of some gabapentin and/or baclofen, they really take the edge of both the physical and mental aspect of kratom with IME, especially the gabapentin. In combination with a benzo, absorbable magnesium, and some cannabis functioning should be pretty easy. If you have decent willpower a proper taper will ease the mental shellshock of suddenly going off opioids.
To answer the second part, it's a terrible idea lol. I tried kratom to get off of fent, smoking a couple 100mcg patches a day for months, and it was brutal even with a ton of 2mg klonopin 30mg restoril and almost unlimited Soma. Lesson learned - smoking fent IS the crack of the opiate world.
And yet i'd extract a patch right now if i had access.I've had luck using fent patches to ease H withdrawal, slapping a couple on and wearing them for a week of two as they slowly wear out. But when i tried that for fent WD it just made it take a lot longer and i ended up ripping them off @ day 4.Luckily i have an appointment with a sub doc wednesday and i'm really hoping he helps me out. Ever since that fent run i have no control. WD'ing from a morphine run as we speak. Kratom, klonopin and soma. And im still miserable. Some of the symptoms of opiate withdrawal are thought to be due to lingering effects of the small amount of residual opioids that remain in the body after the acute effects wear off.
Opioids typically produce inhibitory effects via the mu receptor, but after chronic use some of the receptors show an excitatory response to low concentrations of opioids. So for example with morphine, 12-72 hours after the last dose there is not enough drug in the body to block withdrawal but there is a sufficient amount to produce paradoxical excitatory effects.My point is that anytime you interupt withdrawal by taking another opioid, it will help you feel better but you are just restarting to clock because now you have to detox from the second drug. So it is generally a bad idea to use opioids to treat opioid withdrawal. The exception is if you detox by gradually reducing your dose, because that spreads the withdrawal out over a much longer period.
So I know this sounds a little bit ridiculous but is there any chance that if I wear a 75mcg fentanyl patch for 3 days, that the kratom withdrawals will be more drawn out but less intense? The reason why I say fentanyl is because I tried this approach before for a day and it didn't fully get rid of the withdrawals, maybe only like 30% of the withdrawals, but made it more manageable. So I'm thinking if I wear the patch for 3 days, most of the major withdrawals will be gone, and after I take the patch off I'll just deal with the rest of the two days.What do you guys think? I'm just having one hell of a time trying to get off of it.
Kratom is a comparatively weak opioid compared to either methadone or fentanyl. If you use those to treat kratom withdrawal you will just make your WD worse when you stop the methadone. The issue is, methadone and fentanyl activate the opioid receptors much more completely as well as binding tighter. Kratom does not have the same strength of effect, it is comparatively weak as an opioid, but it does have other activity as a mild adrenaline-releasing stimulant too.Right now your body is used to a certain amount of opioid activation as well as a certain amount of stimulation from the kratom. If you switch from kratom to fentanyl/methadone, you will have a mild w/d initially as your body adjusts to a lack of stimulation, and will adjust to having much stronger opioids as a baseline. As soon as you discontinue methadone/fentanyl you will be back in opioid withdrawal, only worse this time because you've been using a very potent opioid rather than a weak one.You can switch onto methadone/fentanyl and titrate your dose down, but.
Bluelight Kratom High
Why can't you do that with kratom? It will not be any easier trying to decrease your dose of a stronger opioid than a weaker one. As much as it might hurt to hear. Kratom withdrawls are already the easiest they're going to get. Getting onto a stronger opioid will only help you in the short term.
Kratom And Fentanyl Bluelight Drug
If you absolutely demand an opioid for maintenance you should be looking into weak opioids like tramadol and codeine.